Name: Prolia 60mg Injection 1'S
SKU: 8196
Availability: InStock

INTRODUCTION ABOUT PROLIA 60MG INJECTION

PROLIA 60MG INJECTION contains Denosumab which belongs to the group of medicines called Monoclonal antibodies. It is used in adults to manage advanced cancer and to manage serious complications caused by bone metastasis (Ex. fractures, pressure on the spinal cord, radiation therapy, or surgery). It is also used to manage giant cell tumours of the bone, which cannot be managed by surgery, especially in adults whose bones have stopped growing. Symptoms include a visible mass and bone joints being affected (fracture, fluid buildup, limited movement, swelling, and pain in the joints).

Denosumab binds to RANKL, a protein that is essential for the formation, function, and survival of osteoclasts (the cells responsible for bone resorption). It inhibits osteoclast formation, function, and survival, thereby decreasing bone resorption and increasing bone mass and strength. Along with this management, your doctor might ask you to make certain lifestyle changes, such as maintaining good oral hygiene and quitting smoking. Your doctor may ask you to undergo a dental examination before you start the management. PROLIA 60MG INJECTION is not recommended for use in patients with hypocalcemia (low calcium levels in the blood) and unhealed wounds from oral surgery. Before receiving PROLIA 60MG INJECTION, inform your doctor if you have any problems with your mouth or teeth (poor dental health, gum disease, etc.).

PROLIA 60MG INJECTION is not recommended among women who are pregnant. Consult your doctor for advice before receiving PROLIA 60MG INJECTION if you are breast-feeding. PROLIA 60MG INJECTION is not recommended for children and adolescents under 18 years of age, except for adolescents with giant cell tumours of the bone whose bones have stopped growing. The most common side effects of receiving PROLIA 60MG INJECTION are pain in the bones, joints, and muscles, shortness of breath, diarrhea, hypophosphatemia (low phosphate level), and excessive sweating.

USES OF PROLIA 60MG INJECTION

It is used to manage:

Giant cell tumour of bone in adults whose bones have stopped growing
Complications caused by bone metastasis in advanced cancer (fracture, pressure on the spinal cord)

HOW PROLIA 60MG INJECTION WORKS

PROLIA 60MG INJECTION works to slow down bone destruction caused by cancer spreading to the bone (bone metastasis) or by giant cell tumour of bone.

DIRECTIONS FOR USE

PROLIA 60MG INJECTION will usually be administered to you subcutaneously (under the skin) by a doctor or nurse. You should also take calcium and vitamin D supplements while being managed with PROLIA 60MG INJECTION. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF PROLIA 60MG INJECTION

COMMON

Bone, joint, and muscle pain
Shortness of breath, excessive sweating
Diarrhea
Low phosphate levels in the blood (hypophosphatemia)
Development of another form of cancer in patients with advanced cancer

UNCOMMON

High calcium levels in the blood (hypercalcemia) after management stops in patients with giant cell tumours of the bone
New or unusual pain in the hip, groin, or thigh (possible fracture of the thigh bone)
Rash on the skin or sores in the mouth (lichenoid drug eruptions)

RARE

Severe allergic reactions (wheezing or difficulty breathing, swelling of the face, lips, tongue, throat, or other parts of the body, rash, itching, or hives on the skin)

Stop receiving PROLIA 60MG INJECTION and contact your doctor immediately if you experience any of the following side effects:

Osteonecrosis (persistent pain, swelling, non-healing sores, discharge in the mouth and/or jaw, numbness of the jaw, loosening of a tooth)
Signs of low calcium levels in the blood (spasms, twitches, cramps in muscles, numbness or tingling of fingers, toes, or around the mouth; seizures, confusion, or loss of consciousness). It can also lead to a change in heart rhythm

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

PROLIA 60MG INJECTION is not recommended for use if you are pregnant. If you become pregnant during management or in less than 5 months after stopping management, then consult your doctor before receiving it.

BREASTFEEDING

Consult your doctor

It is not known about the excretion of PROLIA 60MG INJECTION in the breast milk. Your doctor will help you decide whether to stop breast-feeding or to stop receiving the management, considering the benefits to the mother and the baby.

DRIVING AND USING MACHINES

Use with Caution

PROLIA 60MG INJECTION has negligible influence on the ability to drive and use machines.

KIDNEY

Use with Caution

PROLIA 60MG INJECTION should be used with caution in patients with severe kidney problems, kidney failure, or who have needed dialysis in the past. Consult your doctor before receiving it.

ALLERGY

Contraindicated

Before receiving PROLIA 60MG INJECTION, inform your doctor if you are allergic to denosumab.

USE IN PEDIATRICS

Contraindicated

PROLIA 60MG INJECTION is not recommended for children and adolescents under 18 years of age, except for adolescents with giant cell tumours of the bone whose bones have stopped growing. Consult your doctor before receiving it.

OTHERS

PROLIA 60MG INJECTION is not recommended for use if you:

Have unmanageed low levels of calcium in the blood
Have unhealed wounds from oral surgery

Before receiving PROLIA 60MG INJECTION, inform your doctor if you:

Have any problems with your mouth or teeth (poor dental health, gum disease, or tooth extraction)
Have not had a dental check-up recently
Have a habit of smoking (increases dental problems)

INTERACTIONS

A. Drug-Drug interactions:

Before receiving PROLIA 60MG INJECTION, inform your doctor if you are taking any of the following medicines:

Another medicine containing denosumab
Bisphosphonate (other medicines used to manage bone loss)

Overdosage:

PROLIA 60MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.

SYNOPSIS

Drug	:	Denosumab
Pharmacological Category	:	RANK ligand inhibitor
Therapeutic Indication	:	Giant cell bone tumour and advanced cancer by bone metastasis
Dosage Forms	:	Injection, prefilled syringes

MORE INFORMATION

STORAGE

Keep PROLIA 60MG INJECTION out of reach of children
Store in a refrigerator at 2-8°C

FAQs ABOUT PROLIA 60MG INJECTION

Q: Can PROLIA 60MG INJECTION cause weight gain?

A: PROLIA 60MG INJECTION has not been associated with weight gain in clinical studies. It can cause peripheral edema (fluid retention) or swelling, which may lead to weight gain in some people.

Q: Is calcium needed along with PROLIA 60MG INJECTION?

A: Yes. You should also take calcium and vitamin D supplements while being managed with PROLIA 60MG INJECTION. Your doctor will discuss the right dosage with you.

Q: Can I undergo dental procedures while receiving PROLIA 60MG INJECTION?

A: If you are under dental management or will undergo dental surgery (Ex. tooth extractions), inform your doctor about it and tell your dentist that you are being managed with PROLIA 60MG INJECTION. If you wear dentures, you should make sure they fit properly. Contact your physician and dentist immediately if you experience any problems with your mouth or teeth (loose teeth, pain or swelling, or non-healing of sores or discharge).

Q: What happens after I stop receiving PROLIA 60MG INJECTION?

A: Some patients with giant cell tumours of the bone have developed high calcium levels in the blood weeks to months after stopping management. Your doctor will monitor you for signs and symptoms of high levels of calcium after you stop receiving PROLIA 60MG INJECTION.